Gerloff B J, Herdt T H, Emery R S, Wells W W
J Anim Sci. 1984 Sep;59(3):806-12. doi: 10.2527/jas1984.593806x.
Fatty liver syndrome or hepatic lipidosis (HL) is a condition thought to contribute to an increased incidence of peripartum disease, reduced response to therapy and decreased fertility in dairy cows. This syndrome is characterized by excess triglyceride (TG) accumulation in the liver and apparent decreased hepatic lipoprotein output. In lactating rats, a similar condition results from feeding an inositol-deficient diet. It is also characterized by excess hepatic TG accumulation and decreased hepatic lipoprotein output. Myo-inositol is a necessary component of the phospholipid phosphatidyl-inositol, which is an important membrane constituent. Myo-inositol occurs in feed mainly as the inositol hexaphosphate phytic acid. Phytic acid is undigestible by the monogastric but rumen phytases are assumed to adequately hydrolyze it. In early lactation dairy cows, lipid mobilization is intense, and the myo-inositol requirement may exceed the dietary supply or availability. Myo-inositol is being tested in a field trial as a potential lipotropic agent for dairy cows. Preliminary results suggest no lipotropic benefit from added myo-inositol.
脂肪肝综合征或肝脂肪变性（HL）是一种被认为会导致奶牛围产期疾病发病率增加、治疗反应降低和繁殖力下降的病症。该综合征的特征是肝脏中甘油三酯（TG）积累过多以及肝脏脂蛋白输出明显减少。在泌乳大鼠中，喂食缺乏肌醇的日粮会导致类似情况。其特征也是肝脏TG积累过多和肝脏脂蛋白输出减少。肌醇是磷脂酰肌醇的必需成分，而磷脂酰肌醇是一种重要的膜成分。肌醇在饲料中主要以肌醇六磷酸植酸的形式存在。植酸单胃动物无法消化，但瘤胃植酸酶被认为能充分水解它。在泌乳早期的奶牛中，脂肪动员强烈，对肌醇的需求可能超过日粮供应或可利用量。肌醇正在作为奶牛潜在的促脂剂进行田间试验。初步结果表明，添加肌醇没有促脂益处。
