Juretić A, Vucak I, Malenica B, Nagy Z A, Klein J
J Immunol. 1984 Dec;133(6):2950-4.
The B10.STA12 mouse congenic line inherited from the wild mouse parent not only the H-2w13 haplotype but also an allele at a minor H locus, which we designate H-41. This allele (H-41a) differentiates the B10.STA12 line from B10.STA10 and B10.LIB55, which carry identical H-2w13 haplotypes but a different H-41 allele (the H-41b, also present in the background strain C57BL/10Sn). The B10.STA12 and B10.STA10 lines reject each other's skin grafts and generate cytolytic T lymphocytes (CTL) after in vivo immunization and in vitro restimulation with cells of the partner strain. The B10.STA12 anti-B10.STA10 CTL react with B10.STA10, B10.LIB55, and B10.STA39 target cells and with cells of F1 hybrids between the responder strain B10.STA12 and strains C57BL/6, C57BL/10, C57L, BALB/c, A, AKR, WB, DBA/1, and DBA/2 but fail to react with (C3H x B10.STA12) F1 and (CBA x B10.STA12) F1 cells. The B10.STA10 anti-B10.STA12 CTL react with B10.STA12, B10.P, and C3H.NB cells but fail to react to (B6 x B10.STA10) F1 target cells. The CTL reactivity in both combinations is Dp restricted. The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain.
源自野生小鼠亲本的B10.STA12小鼠同源近交系不仅继承了H-2w13单倍型，还继承了一个次要组织相容性位点上的一个等位基因，我们将其命名为H-41。该等位基因（H-41a）使B10.STA12品系与B10.STA10和B10.LIB55品系区分开来，后两者携带相同的H-2w13单倍型，但具有不同的H-41等位基因（H-41b，也存在于背景品系C57BL/10Sn中）。B10.STA12和B10.STA10品系相互排斥对方的皮肤移植，并在体内免疫和用对方品系的细胞进行体外再刺激后产生细胞毒性T淋巴细胞（CTL）。B10.STA12抗B10.STA10 CTL与B10.STA10、B10.LIB55和B10.STA39靶细胞以及应答品系B10.STA12与品系C57BL/6、C57BL/10、C57L、BALB/c、A、AKR、WB、DBA/1和DBA/2之间的F1杂种细胞发生反应，但不与（C3H×B10.STA12）F1和（CBA×B10.STA12）F1细胞发生反应。B10.STA10抗B10.STA12 CTL与B10.STA12、B10.P和C3H.NB细胞发生反应，但不与（B6×B10.STA10）F1靶细胞发生反应。两种组合中的CTL反应性均受Dp限制。此外，B10.STA10抗B10.STA12 CTL与B10.SAA48细胞表现出交叉反应性，可能针对该品系H-2单倍型控制的一种同种异体抗原。
