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酿酒酵母有丝分裂周期不同阶段的基因转换。

Gene conversion at different points in the mitotic cycle of Saccharomyces cerevisiae.

作者信息

Fabre F, Boulet A, Roman H

出版信息

Mol Gen Genet. 1984;195(1-2):139-43. doi: 10.1007/BF00332736.

DOI:10.1007/BF00332736
PMID:6387388
Abstract

In the Saccharomyces cerevisiae mitotic cycle, the timing of radiation-induced gene conversion has been studied using thermosensitive cell division cycle mutants. The cells were found to perform conversion at different G1 or post-replication steps. A lower yield in induction is found during the G2 phase and is explained by the competition for recombinational repair between sister chromatids and homologous chromosomes. The results are discussed in relation to repair.

摘要

在酿酒酵母的有丝分裂周期中,利用温度敏感型细胞分裂周期突变体研究了辐射诱导基因转换的时间。发现细胞在不同的G1期或复制后步骤进行转换。在G2期诱导产量较低,这是由于姐妹染色单体和同源染色体之间在重组修复方面的竞争所致。结合修复对结果进行了讨论。

相似文献

1
Gene conversion at different points in the mitotic cycle of Saccharomyces cerevisiae.酿酒酵母有丝分裂周期不同阶段的基因转换。
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2
The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae.PSO4基因负责酿酒酵母中一种易出错的重组DNA修复途径。
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Effect of post-irradiation inhibition of protein synthesis on UV-induced mitotic gene conversion in Saccharomyces cerevisiae.照射后蛋白质合成抑制对酿酒酵母紫外线诱导的有丝分裂基因转换的影响。
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Gene conversion and associated reciprocal recombination are separable events in vegetative cells of Saccharomyces cerevisiae.基因转换及相关的相互重组在酿酒酵母的营养细胞中是可分离的事件。
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本文引用的文献

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INDUCED MITOTIC CROSSING-OVER IN RELATION TO GENETIC REPLICATION IN SYNCHRONOUSLY DIVIDING CELLS OF USTILAGO MAYDIS.黑粉菌同步分裂细胞中诱导有丝分裂交换与基因复制的关系
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Repair of double-strand breaks in a temperature conditional radiation-sensitive mutant of Saccharomyces cerevisiae.酿酒酵母温度条件辐射敏感突变体中双链断裂的修复
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Mitotic recombination: mismatch correction and replicational resolution of Holliday structures formed at the two strand stage in Saccharomyces.
双链 Holliday 连接是 DNA 断裂修复的中间体。
Nature. 2010 Apr 8;464(7290):937-41. doi: 10.1038/nature08868. Epub 2010 Mar 28.
4
From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events.从封面看:用γ射线在 G1 期同步化的酵母细胞中诱导的有丝分裂基因转换事件类似于自发转换事件。
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7383-8. doi: 10.1073/pnas.1001940107. Epub 2010 Mar 15.
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Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination.灰盖鬼伞rad50突变体揭示了Rad50在轴元件和联会复合体形成、同源配对及减数分裂重组中起重要结构作用。
Genetics. 2008 Dec;180(4):1889-907. doi: 10.1534/genetics.108.092775. Epub 2008 Oct 20.
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The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle.细胞周期蛋白依赖性激酶(CDK)通过同源重组调节双链断裂的修复。
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Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants.在酿酒酵母rad9检查点突变体中,拟放射性DNA损伤剂和喜树碱对染色体易位的增强刺激作用。
Mutat Res. 2004 Mar 22;547(1-2):123-32. doi: 10.1016/j.mrfmmm.2003.12.010.
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Characterization of homologous recombination induced by replication inhibition in mammalian cells.哺乳动物细胞中复制抑制诱导的同源重组的特征分析。
EMBO J. 2001 Jul 16;20(14):3861-70. doi: 10.1093/emboj/20.14.3861.
9
Replication-dependent early meiotic requirement for Spo11 and Rad50.Spo11和Rad50在依赖复制的早期减数分裂中的需求
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10477-82. doi: 10.1073/pnas.190346097.
10
Collisions between yeast chromosomal loci in vivo are governed by three layers of organization.酵母染色体位点在体内的碰撞受三层组织架构的调控。
Genes Dev. 1999 Jul 15;13(14):1871-83. doi: 10.1101/gad.13.14.1871.
有丝分裂重组:酿酒酵母中在双链阶段形成的霍利迪结构的错配校正和复制性拆分
Mol Gen Genet. 1981;183(2):252-63. doi: 10.1007/BF00270626.
4
Genetic control of diploid recovery after gamma-irradiation in the yeast Saccharomyces cerevisiae.酿酒酵母经γ射线辐照后二倍体恢复的遗传控制。
Mutat Res. 1980 Dec;73(2):251-65. doi: 10.1016/0027-5107(80)90192-x.
5
Cell-cycle-specific repair of DNA double strand breaks in Saccharomyces cerevisiae.酿酒酵母中DNA双链断裂的细胞周期特异性修复
Radiat Res. 1980 Jun;82(3):547-58.
6
A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae.酿酒酵母中导致染色体分离的基因功能依赖途径。
J Cell Biol. 1982 Sep;94(3):718-26. doi: 10.1083/jcb.94.3.718.
7
Gene conversion and associated reciprocal recombination are separable events in vegetative cells of Saccharomyces cerevisiae.基因转换及相关的相互重组在酿酒酵母的营养细胞中是可分离的事件。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6912-6. doi: 10.1073/pnas.80.22.6912.
8
Yeast recombination: the association between double-strand gap repair and crossing-over.酵母重组:双链缺口修复与交叉互换之间的关联。
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9
Yeast transformation: a model system for the study of recombination.酵母转化:用于重组研究的模型系统。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6354-8. doi: 10.1073/pnas.78.10.6354.
10
The relation of mitotic recombination to DNA replication in yeast pedigrees.酵母谱系中减数分裂重组与DNA复制的关系。
Genetics. 1970 Oct;66(2):291-304. doi: 10.1093/genetics/66.2.291.