O'Brien A D, Newland J W, Miller S F, Holmes R K, Smith H W, Formal S B
Science. 1984 Nov 9;226(4675):694-6. doi: 10.1126/science.6387911.
Escherichia coli K-12 acquired the ability to produce a high titer of Shiga-like toxin after lysogenization by either of two different bacteriophages isolated from a highly toxinogenic Escherichia coli O157:H7 strain that causes hemorrhagic colitis. One of these phages and another Shiga-like toxin-converting phage from an Escherichia coli O26 isolate associated with infantile diarrhea were closely related in terms of morphology, virion polypeptides, DNA restriction fragments, lysogenic immunity, and heat stability, although a difference in host range was noted. These phages are currently the best-characterized representatives from a broader family of Shiga-like toxin-converting phages.
大肠杆菌K-12在被从一株导致出血性结肠炎的高毒力大肠杆菌O157:H7菌株中分离出的两种不同噬菌体中的任何一种溶源化后,获得了产生高滴度志贺样毒素的能力。这些噬菌体中的一种以及另一种来自与婴儿腹泻相关的大肠杆菌O26分离株的志贺样毒素转化噬菌体,在形态、病毒粒子多肽、DNA限制性片段、溶源免疫和热稳定性方面密切相关,尽管宿主范围存在差异。这些噬菌体是目前来自更广泛的志贺样毒素转化噬菌体家族中特征最明确的代表。