Rutoside and the X-ray induced damage in jejunal mucosa of mouse.

The effect of O-(beta-hydroxyethyl)-Rutoside on the radiation response of mouse small intestine was investigated. The post-irradiation mitotic regeneration in jejunal crypts, the survival of crypt stem cells and the post-irradiation mortality of animals were taken as criteria. Multiple treatment with rutoside (300 mg/kg/injection) combined with a whole-body-X-irradiation failed to show protective effect in all the cases studied. Some possibilities which may explain these results are presented.