Savino W, Dardenne M
Eur J Immunol. 1984 Nov;14(11):987-91. doi: 10.1002/eji.1830141105.
The localization of the three best-defined thymic hormones, namely, thymulin, thymopoietin and thymosin alpha 1 was studied by immunofluorescence using antibodies directed against these three molecules. With both human thymus frozen sections and cultured cells, thymic hormones were found exclusively in the epithelial component (recognized by its keratin content), in normal as well as pathological thymuses. The double-labeling experiments using the different anti-thymic hormone antibodies showed that the same epithelial cells contained the three hormones. These results suggest that the production of different hormones in the thymus is accomplished by the same epithelial cells.
利用针对这三种分子的抗体，通过免疫荧光法研究了三种最明确的胸腺激素，即胸腺素、胸腺生成素和α1胸腺素的定位。在人胸腺冰冻切片和培养细胞中，无论是正常胸腺还是病理胸腺，胸腺激素仅存在于上皮成分中（通过其角蛋白含量识别）。使用不同抗胸腺激素抗体的双重标记实验表明，相同的上皮细胞含有这三种激素。这些结果表明，胸腺中不同激素的产生是由相同的上皮细胞完成的。
