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实验室条件下灵长类动物放射性肾造影麻醉的标准化

Standardization of anaesthesia for radiorenography with primates under laboratory conditions.

作者信息

Dormehl I C, Jacobs D J, du Plessis M, Goosen D J

出版信息

J Med Primatol. 1984;13(1):5-10.

PMID:6389883
Abstract

The influence of thiopentone intravenous infusion or halothane inhalation on the results of radiorenography was evaluated using, in six chacma baboons (Papio ursinus), 99mTc-diethyltriamine-pentaacetic acid (DTPA) as scanning agent. The renogram parameters, which depend on the condition of the cardiovascular system, differed significantly for the two anaesthetic agents. Since anaesthesia is necessary in baboon studies for the duration of renogram acquisition, it is imperative to standardize an experimental procedure which will leave the cardiovascular system relatively stable. From this investigation it seemed most appropriate to use as an anaesthetic a constant intravenous infusion of thiopentone.

摘要

使用99mTc-二乙三胺五乙酸(DTPA)作为扫描剂,在六只东非狒狒(山魈)身上评估硫喷妥钠静脉输注或氟烷吸入对放射性肾图结果的影响。这两种麻醉剂的肾图参数(其取决于心血管系统状况)存在显著差异。由于在狒狒研究中进行肾图采集期间需要麻醉,因此必须规范一种能使心血管系统相对稳定的实验程序。从这项研究来看,使用硫喷妥钠持续静脉输注作为麻醉剂似乎最为合适。

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