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虹鳟鱼(Salmo gairdneri)的脑-垂体-性腺轴。III. 睾酮对幼鱼促性腺激素释放无抑制作用。

The brain-pituitary-gonadal axis in the rainbow trout, Salmo gairdneri. III. Absence of an inhibiting action of testosterone on gonadotrophin release in juveniles.

作者信息

Gielen J T, Goos H J

出版信息

Gen Comp Endocrinol. 1984 Dec;56(3):457-65. doi: 10.1016/0016-6480(84)90088-1.

Abstract

In juvenile rainbow trout the effects of exogenous testosterone and of a synthetic gonadotrophin-releasing hormone (GnRH) on the secretion of gonadotrophin (GTH) were investigated. Treatment with implanted testosterone resulted in an accumulation of GTH in the pituitary, but did not affect the concentration of GTH in the plasma. After the testosterone implants were removed, the levels of testosterone in the circulation dropped to undetectable or control values, but the concentration of GTH in the plasma did not increase. These results indicate that testosterone stimulated the synthesis and storage of GTH, and did not prevent the release of this hormone. The synthetic GnRH, des-Gly10[D-Ala6]LH-RH ethylamide (LH-RHa) stimulated the release of GTH when injected into testosterone-pretreated fish, indicating that accumulated GTH is present in a releasable pool.

摘要

研究了外源性睾酮和合成促性腺激素释放激素(GnRH)对幼年虹鳟促性腺激素(GTH)分泌的影响。植入睾酮处理导致垂体中GTH积累,但不影响血浆中GTH的浓度。去除睾酮植入物后,循环中的睾酮水平降至无法检测或对照值,但血浆中GTH的浓度并未增加。这些结果表明,睾酮刺激了GTH的合成和储存,并且不阻止这种激素的释放。当将合成GnRH,即去甘氨酸10[D-丙氨酸6]促黄体激素释放激素乙酰胺(LH-RHa)注射到经睾酮预处理的鱼中时,刺激了GTH的释放,这表明积累的GTH存在于可释放池中。

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