Myc蛋白在有丝分裂细胞中不与染色质相关联。

Winqvist R, Saksela K, Alitalo K

EMBO J. 1984 Dec 1;3(12):2947-50. doi: 10.1002/j.1460-2075.1984.tb02237.x.

The protein products of cellular and viral myc oncogenes are detected in nuclei by immunofluorescence. No myc fluorescence is found in nucleoli. In mitotic cells the myc antigens are not found associated with metaphase chromosomes, but are diffusely distributed throughout the cytoplasm. Cytoplasmic myc fluorescence is first observed when chromatin begins to condense in early prophase. Granular nuclear myc fluorescence is again discerned in telophase cells, when the nuclear envelope is formed and becomes more prominent upon cytokinesis; concomitantly the diffuse cytoplasmic myc staining is lost. These results suggest that myc proteins not only bind to DNA or chromatin, but are also associated with other structural systems in the nuclei.

通过免疫荧光法可在细胞核中检测到细胞和病毒的myc癌基因的蛋白质产物。在核仁中未发现myc荧光。在有丝分裂细胞中，未发现myc抗原与中期染色体相关联，而是弥散分布于整个细胞质中。当染色质在前期早期开始浓缩时，首次观察到细胞质中的myc荧光。在末期细胞中，当核膜形成并在胞质分裂时变得更加明显时，再次观察到颗粒状的核myc荧光；与此同时，弥散的细胞质myc染色消失。这些结果表明，myc蛋白不仅与DNA或染色质结合，还与细胞核中的其他结构系统相关联。