Shohat B, Shapira Z, Servadio C
Dev Biol Stand. 1984;57:361-6.
Three different methods (theophylline sensitivity, monoclonal antibodies and a local xenogeneic graft-versus-host reaction) were used to study the T-cell subsets in two renal allograft recipients, one who was treated with cyclosporin-A + prednisone after having received preoperative gradual lymphoid irradiation and one who was treated by conventional methods following transplantation. In the patient treated with cyclosporin-A, who experienced no clinical rejection and has been in good condition during four months of follow-up, the percentage of theophylline-sensitive TS cells rose from 3% following irradiation to 38% one week after transplantation and treatment; T suppressor cells tested by OKT8 antibodies ranged from 60% to 100% whereas the helper cells tested by OKT4 ranged from 10% to 40%, with a ratio of OKT4/OKT8 below 0.6. In the patient receiving conventional treatment, who underwent unresponsive acute renal rejection 21 days after transplantation, the level of suppressor cells was much lower, ranging from 12% to 42%, with the OKT4/OKT8 ratio ranging from 1.47 to 2.5.
采用三种不同方法（茶碱敏感性、单克隆抗体及局部异种移植物抗宿主反应）对两名肾移植受者的T细胞亚群进行研究，一名受者在术前接受逐步淋巴细胞照射后接受环孢素A + 泼尼松治疗，另一名受者在移植后采用传统方法治疗。在接受环孢素A治疗的患者中，未发生临床排斥反应，随访4个月情况良好，茶碱敏感的TS细胞百分比从照射后的3%升至移植及治疗后1周的38%；用OKT8抗体检测的T抑制细胞范围为60%至100%，而用OKT4检测的辅助细胞范围为10%至40%，OKT4/OKT8比值低于0.6。在接受传统治疗的患者中，移植后21天发生无反应性急性肾排斥，其抑制细胞水平低得多，范围为12%至42%，OKT4/OKT8比值范围为1.47至2.5。
