White S W
Int J Dermatol. 1984 Dec;23(10):656-7. doi: 10.1111/j.1365-4362.1984.tb01226.x.
Chronic edema can be debilitating in Noonan's syndrome. Transient childhood lymphedema may be followed by elephantiasis as early as adolescence. Recurrent streptococcal cellulitis exacerbates this problem. Hygenic measures and prophylactic antiobiotic therapy may slow progression of lymphedema of the legs in Noonan's syndrome.
慢性水肿在努南综合征中可能使人虚弱。短暂的儿童期淋巴水肿可能早在青春期就会发展为象皮病。复发性链球菌蜂窝织炎会加剧这一问题。卫生措施和预防性抗生素治疗可能会减缓努南综合征患者腿部淋巴水肿的进展。
