[长春地辛、达卡巴嗪和顺铂隔离肢体热灌注治疗恶性黑色素瘤]

[Isolated hyperthermic extremity perfusion with vindesine, dacarbazine and cisplatin in the treatment of malignant melanomas].

作者信息

Aigner K R, Jungbluth A, Link K H, Walther H, Müller H, Schwemmle K, Ringenberg T, Börger G, Ruppel R, Illig L

出版信息

Onkologie. 1984 Dec;7(6):348-53. doi: 10.1159/000215480.

Abstract

A three drug combination consisting of dacarbazine, vindesine and CDDP (DVP) was used for isolated extremity perfusion in 26 patients with stage I, II and III melanomas of the limbs. Dosages of 100 mg/l dacarbazine, 0.4 mg/l vindesine and 20 mg Cis-Platinum/l extremity volume have been tolerated without major side effects. All perfusions of bulky tumors or metastases resulted in more than 50% tumor-size reduction (8 patients stage III A, 6 patients stage III AB). In five stage III patients relapse occurred 2, 3, 5, 6 months after isolated DVP perfusion.

摘要

一种由达卡巴嗪、长春地辛和顺铂（DVP）组成的三联药物组合被用于26例肢体I期、II期和III期黑色素瘤患者的肢体隔离灌注。达卡巴嗪剂量为100mg/l、长春地辛剂量为0.4mg/l以及顺铂剂量为20mg/肢体容积均被耐受，且无严重副作用。所有对体积较大的肿瘤或转移灶进行的灌注均使肿瘤大小缩小超过50%（8例III A期患者，6例III AB期患者）。在5例III期患者中，隔离DVP灌注后2、3、5、6个月出现复发。