顺铂和达卡巴嗪区域灌注

Regional perfusion with cis-platinum and dacarbazine.

作者信息

Aigner K, Hild P, Henneking K, Paul E, Hundeiker M

出版信息

Recent Results Cancer Res. 1983;86:239-45. doi: 10.1007/978-3-642-82025-0_40.

DOI:10.1007/978-3-642-82025-0_40

Abstract

In 22 patients isolated extremity perfusion with cis-platinum for treatment of malignant melanoma was performed; 18 had local metastastic disease (M. D. Anderson stages II and III A, B, AB) and four were stage I. A further five patients were submitted to isolated DTIC perfusion. DTIC-perfused tumors showed regression rates of 30%-80%, followed by recurrences within 4 months. After cis-platinum perfusion stage-III AB cases tended to show tumor recurrence within 4 months, while to date stage-III A and stage-II cases have reached disease-free survival times of 17 and 20 months respectively. While in DTIC perfusion the tissue temperature may range between 40 degrees and 41 degrees C, in cis-platinum perfusions 40 degrees C should not be exceeded; otherwise neural damage will occur.

摘要

对22例患者进行了顺铂肢体隔离灌注以治疗恶性黑色素瘤；18例有局部转移性疾病（MD安德森分期II期和III A、B、AB期），4例为I期。另有5例患者接受了达卡巴嗪隔离灌注。接受达卡巴嗪灌注的肿瘤显示出30%-80%的消退率，随后在4个月内复发。顺铂灌注后，III AB期病例倾向于在4个月内出现肿瘤复发，而迄今为止，III A期和II期病例分别达到了17个月和20个月的无病生存期。在达卡巴嗪灌注时，组织温度可能在40摄氏度至41摄氏度之间，而在顺铂灌注时，不应超过40摄氏度；否则会发生神经损伤。