Dzhikidze E K, Shaginian S A, Pospelova V V, Rakhimova N G, Voroshilina N N
Zh Mikrobiol Epidemiol Immunobiol. 1984 Dec(12):44-8.
The study of the qualitative and quantitative composition of intestinal microflora in 15 anthropoid apes, 60 lower primates and 72 monkeys with clinically pronounced dysbacteriosis was made, which revealed the prevalence of microorganisms belonging to the genus Proteus, a decrease in the biological activity of normal Escherichia coli and in the content of bifido- and lactobacteria. The treatment of 39 rhesus and pig-tailed macaques with the preparations of live bacteria occurring in normal human microflora led to clinical convalescence and the normalization of the bacteriocenosis, while in 33 control animals no positive shifts in clinical and bacteriological data were observed. The essential similarity of the composition of intestinal microflora in higher and lower primates and in man makes it possible to use these animals as models for testing the effectiveness of new biological preparations and determines the expediency of using bacterial therapy for the treatment of monkeys at the period of acclimatization.
对15只类人猿、60只低等灵长类动物和72只患有临床明显菌群失调的猴子的肠道微生物群的定性和定量组成进行了研究，结果显示变形杆菌属微生物占优势，正常大肠杆菌的生物活性以及双歧杆菌和乳酸菌的含量降低。用存在于正常人类微生物群中的活细菌制剂治疗39只恒河猴和豚尾猕猴，导致临床康复和细菌群落正常化，而在33只对照动物中，未观察到临床和细菌学数据的积极变化。高等和低等灵长类动物以及人类肠道微生物群组成的基本相似性使得可以将这些动物用作测试新生物制剂有效性的模型，并确定在适应期对猴子使用细菌疗法的适宜性。
