恶性肿瘤的光动力疗法（PDT）。

Photodynamic therapy (PDT) of malignant tumors.

作者信息

Dougherty T J

出版信息

Crit Rev Oncol Hematol. 1984;2(2):83-116. doi: 10.1016/s1040-8428(84)80016-5.

Abstract

Photodynamic therapy (PDT) is finding increasing application to a number of malignant tumors. It is based on the specific photosensitization of malignant tissue by a particular porphyrin derived from hematoporphyrin, known as Photofrin II. The exact structure at present is unknown. However this material, following systemic injection, is retained longer in malignant tissue than in many normal tissues and can be activated by visible light, usually red, to initiate a lethal phototoxic effect on the tumor. It is a particularly useful treatment when specificity is necessary in treatment, for example in treatment of widespread chest wall metastasis, bladder cancer and early lesions of the bronchus, trachea and esophagus, including CIS.

摘要

光动力疗法（PDT）在多种恶性肿瘤中的应用越来越广泛。它基于一种由血卟啉衍生而来的特定卟啉（称为光敏素II）对恶性组织的特异性光敏化作用。目前其确切结构尚不清楚。然而，这种物质在全身注射后，在恶性组织中的保留时间比许多正常组织更长，并且可以被可见光（通常是红光）激活，从而对肿瘤引发致命的光毒性效应。当治疗需要特异性时，例如在治疗广泛的胸壁转移、膀胱癌以及支气管、气管和食管的早期病变（包括原位癌）时，它是一种特别有用的治疗方法。