Donati M B, Semeraro N
Haemostasis. 1984;14(5):422-9. doi: 10.1159/000215100.
Cancer cells may promote fibrin formation in the tumor microenvironment through availability of procoagulant activities which are mainly of two types: tissue thromboplastin-like or direct activator of coagulation factor X. The pharmacological modulation of these activities could be potentially important in the control of metastasis growth. However, very limited information is available so far on this issue; it has recently been shown that the direct activator of coagulation factor X is a vitamin K-dependent activity which is depressed by warfarin treatment, not by anticoagulation with heparin or defibrinating enzymes. Whether the inhibition of this peculiar cancer procoagulant is involved in the antimetastatic activity of warfarin is a stimulating hypothesis which needs to be further substantiated.
癌细胞可通过促凝血活性在肿瘤微环境中促进纤维蛋白形成，促凝血活性主要有两种类型：组织凝血活酶样或凝血因子X的直接激活剂。对这些活性进行药理调节在控制转移瘤生长方面可能具有重要意义。然而，目前关于这个问题的信息非常有限；最近有研究表明，凝血因子X的直接激活剂是一种维生素K依赖性活性，可被华法林治疗抑制，而不是被肝素或去纤酶抗凝抑制。这种特殊的癌症促凝剂的抑制是否参与华法林的抗转移活性，是一个需要进一步证实的有趣假设。
