华法林可抑制Lewis肺癌细胞的促凝血活性和转移能力。维生素K缺乏的作用。

Warfarin inhibits both procoagulant activity and metastatic capacity of Lewis lung carcinoma cells. Role of vitamin K deficiency.

作者信息

Colucci M, Delaini F, de Bellis Vitti G, Locati D, Poggi A, Semeraro N, Donati M B

出版信息

Biochem Pharmacol. 1983 Jun 1;32(11):1689-91. doi: 10.1016/0006-2952(83)90110-7.

Abstract

Chronic vitamin K deficiency, either dietary or pharmacologically induced with warfarin, depressed significantly the growth of lung secondaries in a spontaneously metastasizing murine tumor, the Lewis Lung Carcinoma. This effect was associated with a marked depression of the procoagulant activity of cancer cells, which could contribute to fibrin deposition around the tumor. Cellular anticoagulation may thus be an important mechanism in the antimetastatic effect of warfarin.

摘要

慢性维生素K缺乏，无论是饮食引起的还是华法林药物诱导的，都会显著抑制自发转移的小鼠肿瘤——Lewis肺癌肺转移灶的生长。这种效应与癌细胞促凝活性的显著降低有关，而癌细胞促凝活性的降低可能有助于肿瘤周围的纤维蛋白沉积。因此，细胞抗凝可能是华法林抗转移作用的一个重要机制。