Andreasen F, Hansen H E, Mikkelsen E
Eur J Clin Pharmacol. 1978 Mar 17;13(1):41-8. doi: 10.1007/BF00606681.
The pharmacokinetics of furosemide 40 mg i.v. were compared in 7 anephric patients and in 7 normal subjects. The average serum clearance was 66 ml/min in the patients and 219 ml/min in the normal subjects, and the corresponding weight corrected clearances were 1.33 ml/min . kg and 2.96 ml/min . kg. Binding to serum proteins was significantly decreased in the anephric subjects, in whom a significant negative correlation was found between the percentage binding and the volume of distribution VDSS. In the patients, but not in the normal subjects, there was a significant positive correlation between VDSS and serum clearance. Both in normal and anephric individuals 4-chlor-5-sulphamoyl-anthranilic-acid (CSA) was found, but there was no evidence of special accumulation either of CSA or anthranilic acid in the anephric patients. In the patients the initial increase in serum concentration of sodium and protein followed by a more conspicuous decrease were more pronounced, but none of the changes were statistically significant.
对7例无肾患者和7例正常受试者静脉注射40毫克呋塞米后的药代动力学进行了比较。患者的平均血清清除率为66毫升/分钟，正常受试者为219毫升/分钟，相应的体重校正清除率分别为1.33毫升/分钟·千克和2.96毫升/分钟·千克。无肾受试者与血清蛋白的结合显著降低，在这些受试者中，结合百分比与分布容积VDSS之间存在显著负相关。在患者中，而非正常受试者中，VDSS与血清清除率之间存在显著正相关。在正常人和无肾个体中均发现了4-氯-5-氨磺酰基-邻氨基苯甲酸（CSA），但没有证据表明无肾患者中CSA或邻氨基苯甲酸有特殊蓄积。患者血清钠和蛋白浓度最初升高，随后更为明显地降低，但这些变化均无统计学意义。
