Stern N, Sowers J R, Tuck M, Eshkol A, Lunenfeld B, Rosenthal T
J Hypertens. 1984 Apr;2(2):209-14. doi: 10.1097/00004872-198404000-00014.
Aldosterone responses to posture and the dopamine antagonist, metoclopramide, were studied in seven normotensive controls and 12 patients with essential hypertension. Both groups had similar basal supine plasma renin activity and aldosterone levels. Aldosterone levels of the hypertensive patients were greater than those of the controls 10 min after assuming an upright posture but indistinguishable at 120 min. Metoclopramide induced a peak fourfold increase above basal aldosterone levels in the hypertensive group as compared to a peak twofold increase observed in the normotensive controls. Mean 120-min integrated aldosterone response area for the hypertensives (237 +/- 44 10(-10) mol min/l) was greater (P less than 0.05) than that for normotensive subjects (106 +/- 32 10(-10) mol min/l). Simultaneous cortisol, plasma renin activity, and serum potassium levels were unaffected by metoclopramide. It is concluded that dopaminergic modulation of aldosterone secretion may be altered in essential hypertension.
在7名血压正常的对照者和12名原发性高血压患者中研究了醛固酮对体位及多巴胺拮抗剂甲氧氯普胺的反应。两组的基础仰卧位血浆肾素活性和醛固酮水平相似。高血压患者在采取直立姿势10分钟后的醛固酮水平高于对照者，但在120分钟时无差异。与血压正常的对照者中观察到的醛固酮水平峰值两倍升高相比，甲氧氯普胺使高血压组的醛固酮水平峰值高于基础值四倍。高血压患者的平均120分钟醛固酮综合反应面积（237±44×10⁻¹⁰mol·min/L）大于血压正常者（106±32×10⁻¹⁰mol·min/L）（P<0.05）。同时，皮质醇、血浆肾素活性和血清钾水平不受甲氧氯普胺影响。结论是，原发性高血压患者醛固酮分泌的多巴胺能调节可能发生改变。
