Fiselier T J, Monnens L A, Lameire N H, van Munster P J, Peer P G, Leusen I R, Lijnen P J
Kidney Int. 1984 Dec;26(6):823-9. doi: 10.1038/ki.1984.224.
The objective of this study was to investigate the relationship between the high activity of the renin-angiotensin-aldosterone system (RAAS) and the control of blood pressure and aldosterone in the canine puppy. The effect of the angiotensin II analog saralasin on arterial pressure (MAP), plasma renin activity (PRA), plasma renin concentration (PRC), and aldosterone (PA) was studied in unanesthetized normal, salt-loaded and salt-depleted puppies aged 9 to 30 days. Salt-loading was performed by daily intraperitoneal administration of 10 mEq sodium/kg body weight for 5 days and salt-depletion by furosemide injections. Saralasin infusion, 6 micrograms/kg/min, during 60 min significantly decreased MAP and increased PRC not only in salt-depleted puppies, as has been observed in adult salt-depleted dogs, but also in normal puppies (mean fall, 6.6 mm Hg). Although any developmental changes in the RAAS and MAP and in their relationship could not be ascertained, the fall in MAP during saralasin in normal puppies was significantly correlated to presaralasin renin values (r = 0.76, P less than 0.01, N = 11). PA did not change in both groups of puppies. In salt-loaded puppies saralasin caused no change of MAP, PRC, and PA. We conclude that the high renin levels at young age contribute to the basal arterial pressure in puppies.
本研究的目的是探讨幼犬肾素-血管紧张素-醛固酮系统（RAAS）的高活性与血压及醛固酮控制之间的关系。在9至30日龄未麻醉的正常、高盐负荷和低盐负荷幼犬中，研究了血管紧张素II类似物沙拉新对动脉压（MAP）、血浆肾素活性（PRA）、血浆肾素浓度（PRC）和醛固酮（PA）的影响。高盐负荷通过每天腹腔注射10 mEq钠/千克体重，持续5天来实现，低盐负荷则通过注射速尿来实现。以6微克/千克/分钟的速度输注沙拉新60分钟，不仅在低盐负荷的幼犬中（正如在成年低盐负荷犬中所观察到的那样），而且在正常幼犬中（平均下降6.6毫米汞柱），均显著降低了MAP并升高了PRC。尽管无法确定RAAS和MAP及其关系的任何发育变化，但正常幼犬在输注沙拉新期间MAP的下降与输注沙拉新前的肾素值显著相关（r = 0.76，P < 0.01，N = 11）。两组幼犬的PA均未发生变化。在高盐负荷的幼犬中，沙拉新对MAP、PRC和PA均无影响。我们得出结论，幼犬年轻时的高肾素水平有助于其基础动脉压的维持。
