Goetz K L, Wang B C, Sundet W D
J Physiol (Paris). 1984;79(6):440-5.
Increases in plasma vasopressin and renin activity that occur in response to haemorrhage have been attributed in part to reflex effects from cardiac receptors and sinoaortic baroreceptors, but the relative importance of these different receptors in causing humoral changes during haemorrhage in conscious dogs has not been reported. We investigated this question by hemorrhaging 6 sham-operated (SO), 6 cardiac-denervated (CD), 4 sinoaortic-denervated (SAD), and 4 combined sinoaortic and cardiac-denervated (SACD), conscious dogs. Blood was removed at a rate of 0.9 ml/kg X min. Plasma vasopressin and renin samples were taken during a control period and after 10, 20, and 30 ml/kg of blood had been removed. Results (mean +/- SE) are shown in the tables below. (table; see text) These experiments illustrate that: resting plasma levels of vasopressin and renin in conscious dogs are unaffected by the denervation procedures used in these experiments, the increase in plasma vasopressin that occurs during haemorrhage is mediated largely via cardiac receptors, with a considerably smaller contribution from the sinoaortic baroreceptors, during moderately severe haemorrhage (30 ml/kg) vasopressin secretion can be increased by a mechanism independent of sinoaortic and cardiac reflexes, the increase in plasma renin activity that occurs during haemorrhage is not dependent upon either cardiac or sinoaortic reflexes.
因出血而出现的血浆血管加压素和肾素活性增加，部分归因于心脏感受器和窦主动脉压力感受器的反射作用，但在清醒犬类出血过程中，这些不同感受器在引起体液变化方面的相对重要性尚未见报道。我们通过对6只假手术（SO）、6只心脏去神经支配（CD）、4只窦主动脉去神经支配（SAD）和4只窦主动脉与心脏联合去神经支配（SACD）的清醒犬进行出血实验来研究这个问题。以0.9毫升/千克×分钟的速率抽血。在对照期以及抽取10、20和30毫升/千克血液后采集血浆血管加压素和肾素样本。结果（均值±标准误）如下表所示。（表格；见正文）这些实验表明：清醒犬类静息血浆中血管加压素和肾素水平不受本实验中所用去神经支配程序的影响；出血期间血浆血管加压素的增加主要通过心脏感受器介导，窦主动脉压力感受器的作用小得多；在中度严重出血（30毫升/千克）时，血管加压素分泌可通过一种独立于窦主动脉和心脏反射的机制增加；出血期间血浆肾素活性的增加不依赖于心脏或窦主动脉反射。
