选定的阿片类药物、乙醇及乙醇摄入量。

Selected opioids, ethanol and intake of ethanol.

作者信息

Hunter G A, Beaman C M, Dunn L L, Reid L D

出版信息

Alcohol. 1984 Jan-Feb;1(1):43-6. doi: 10.1016/0741-8329(84)90035-1.

Abstract

Rats were given an opportunity to drink tap water or a sweetened ethanol solution once a day. Across initial days of opportunity, rats increased their intake of the ethanol solution. Prior to some days' sessions with presented fluids, rats received either an injection of placebo (the carrier of drugs) or doses of ethylketocyclozocine, diprenorphine, or ethanol. Diprenorphine increased rats' intake of the ethanol solution compared to placebo. The other agents did not reliably modify intakes. These findings support a conclusion that selected activity in opioid systems of brain increase the propensity to drink alcoholic beverages.

摘要

大鼠每天有一次机会饮用自来水或甜味乙醇溶液。在最初有机会饮用的日子里，大鼠增加了乙醇溶液的摄入量。在某些有液体供应的实验日之前，大鼠接受了安慰剂（药物载体）注射或不同剂量的乙基酮环佐辛、二丙诺啡或乙醇注射。与安慰剂相比，二丙诺啡增加了大鼠对乙醇溶液的摄入量。其他药物未能可靠地改变摄入量。这些发现支持了这样一个结论，即大脑阿片系统中的特定活动会增加饮用酒精饮料的倾向。