Townsend H A, Waddy A L, Eason C T, Richards H H
Curr Med Res Opin. 1984;9(2):132-40. doi: 10.1185/03007998409109571.
A total of 95 patients seen in general practice with oedema associated with heart failure took part in an open study of the efficacy and tolerability of a combination tablet containing 40 mg frusemide and 5 mg amiloride. The study was of 3-months' duration and patients received a dosage of 1 to 2 tablets once daily. Efficacy was assessed by physicians' scores for ankle, leg and lumbosacral oedema and pulmonary crepitations, body weight and physicians' global clinical impression. In addition, patients recorded their symptom severity in study diaries during the first 7 days of therapy, and the day before each trial visit. On the basis of the physicians' overall impression of response to therapy, 89 (93.7%) of the patients were graded as 'excellent', 'good' or 'adequate' responders. Improvement in severity scores for oedema, crepitations and body weight also followed this pattern, although certain symptoms were mild or absent in some patients at recruitment. Nine patients were withdrawn from the study, 4 due to drug-related adverse effects. There was no evidence of any consistent change in serum potassium levels or other clinical chemistry, liver function tests or haematology during the study.
共有95例因心力衰竭出现水肿的全科门诊患者参与了一项关于含40毫克速尿和5毫克阿米洛利的复方片剂疗效及耐受性的开放性研究。该研究为期3个月，患者每日服用1至2片的剂量。疗效通过医生对脚踝、腿部和腰骶部水肿及肺部啰音、体重的评分以及医生的整体临床印象来评估。此外，患者在治疗的前7天以及每次试验访视前一天在研究日记中记录症状严重程度。根据医生对治疗反应的总体印象，89名（93.7%）患者被评为“优秀”、“良好”或“适当”的反应者。水肿、啰音和体重严重程度评分的改善也遵循这一模式，尽管部分患者在入组时某些症状较轻或不存在。9名患者退出研究，4名因药物相关不良反应。研究期间，血清钾水平或其他临床化学指标、肝功能检查或血液学检查均未出现任何持续变化的迹象。
