Bernstein J J, Underberger D, Hoovler D W
Cent Nerv Syst Trauma. 1984 Fall;1(1):39-46. doi: 10.1089/cns.1984.1.39.
Transplantation of 11 day gestation rat fetal cortex and spinal cord into adult rat thoracic spinal cord is feasible. However, the techniques used at present for the implantation of the fetal transplant result in host spinal gray matter necrosis. One day after implantation the transplant is in a fluid-filled cyst in the host. The transplanted fetal tissue forms spherical neuroepithelia and unorganized cellular arrays. At Day 3 after transplantation the implant has sedimented to the ventral aspects of the fluid-filled cyst. By 10 days, there is an active neuroepithium with differentiating neurons and neuroglia lining the basal portion of the cyst. The transplant then proceeds to fill the cavity formed by host phagocytosis of the debris in the fluid-filled cyst.
将妊娠11天的大鼠胚胎皮质和脊髓移植到成年大鼠胸段脊髓是可行的。然而，目前用于植入胎儿移植物的技术会导致宿主脊髓灰质坏死。植入后一天，移植物位于宿主体内充满液体的囊肿中。移植的胎儿组织形成球形神经上皮和无组织的细胞阵列。移植后第3天，移植物已沉积到充满液体的囊肿的腹侧。到第10天时，有一个活跃的神经上皮，囊肿底部有正在分化的神经元和神经胶质细胞排列。然后移植物开始填充由宿主吞噬充满液体的囊肿中的碎片所形成的腔隙。
