Murakami K
J Hypertens Suppl. 1984 Dec;2(3):S285-7.
A complete amino acid sequence of human renin was deduced from its complementary DNA (cDNA) sequence. Close similarities were observed in the primary structure of human renin and other aspartyl proteinases. A three-dimensional model of human renin has been constructed assuming that the overall folding of the aspartyl proteinases is very similar. The model is consistent with many biochemical and catalytic properties of human renin previously reported, thereby confirming its usefulness and the strong correspondence between the model and the actual structure of renin. The model should provide the structural basis for the development of a potentially-useful antihypertensive drug.
从人肾素的互补DNA（cDNA）序列推导出了其完整的氨基酸序列。在人肾素和其他天冬氨酸蛋白酶的一级结构中观察到了密切的相似性。假定天冬氨酸蛋白酶的整体折叠非常相似，构建了人肾素的三维模型。该模型与先前报道的人肾素的许多生化和催化特性一致，从而证实了其有用性以及该模型与肾素实际结构之间的高度对应性。该模型应为开发一种潜在有用的抗高血压药物提供结构基础。
