Scott D W
Crit Rev Immunol. 1984;5(1):1-25.
Self:nonself-discrimination is critical for the function of the immune system and survival of vertebrate species. The failure to respond to one's own antigens has been called self-tolerance. The mechanisms whereby such tolerance may be induced are reviewed herein. Emphasis is placed on the role of self-recognition involving suppressor T-cell pathways as well as on studies involving putative clonal deletion mechanisms. The important parameters for the induction of tolerance and the roles played by surface isotypes in discriminating immunogenic vs. tolerogenic signals will be emphasized. The possible involvement of multiple pathways for self or experimental tolerance is emphasized with the ultimate goal being the modulation of aberrant immune responses.
自我与非自我的区分对于免疫系统的功能和脊椎动物物种的生存至关重要。对自身抗原无反应被称为自我耐受。本文综述了诱导这种耐受的机制。重点强调了涉及抑制性T细胞途径的自我识别作用以及涉及假定克隆清除机制的研究。将着重讨论诱导耐受的重要参数以及表面同种型在区分免疫原性与耐受性信号中所起的作用。强调了自我耐受或实验性耐受可能涉及多种途径，最终目标是调节异常的免疫反应。
