Hickman J G
Clin Dermatol. 1983 Jul-Sep;1(1):102-13. doi: 10.1016/0738-081x(83)90045-7.
Since its description 50 years ago, pyoderma gangrenosum has continued to capture the attention and imagination of all those who see its dramatic presentation. Clinical observation still provides the only reliable diagnosis. As investigative techniques increase, more and more intriguing immunologic abnormalities associated with this disorder are discovered, but understanding of the pathogenesis remains elusive. It is now recognized as an independent condition as well as a co-condition with many systemic disorders. Many new treatment options are available, allowing much individualization of treatment. For now, pyoderma gangrenosum remains an impressive, relatively easily recognized, but poorly understood disease.
自50年前被描述以来，坏疽性脓皮病一直吸引着所有目睹其戏剧性表现者的关注和想象。临床观察仍是唯一可靠的诊断方法。随着研究技术的不断进步，越来越多与该疾病相关的有趣免疫异常被发现，但对其发病机制的理解仍很模糊。它现在被认为是一种独立的疾病，也是许多全身性疾病的伴随疾病。有许多新的治疗选择，使得治疗能够更多地个体化。目前，坏疽性脓皮病仍然是一种令人印象深刻、相对容易识别但了解甚少的疾病。
