Adinolfi A, Adinolfi M, Massa O
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Exp Clin Immunogenet. 1984;1(4):208-16.
Rabbit immune sera against human alcohol dehydrogenase (ADH) isozymes were found to cross-react with mouse ADH. The immune serum raised against horse ADH and specific for the human isozymes coded at the ADH1, ADH2 and ADH3 loci (class I of ADH isozymes) reacted with the ADH-A2 isozyme from mouse liver and ADH-C2 isozyme from mouse stomach. The two mouse isozymes exhibit partial immunological identity. The immune serum raised against the human chi-ADH isozyme coded at the ADH5 locus (class III of ADH isozymes) reacted with the ADH-B2 isozyme from mouse stomach and liver. The results indicate that the A2 and C2 forms of mouse ADH may be related to the human ADH isozymes coded at the ADH1, ADH2 and ADH3 loci whereas the B2 form may be homologous of the human ADH isozyme coded at the ADH5 locus.
已发现抗人乙醇脱氢酶（ADH）同工酶的兔免疫血清与小鼠ADH发生交叉反应。针对马ADH产生的、对ADH1、ADH2和ADH3位点编码的人同工酶（ADH同工酶I类）具有特异性的免疫血清，与小鼠肝脏中的ADH-A2同工酶和小鼠胃中的ADH-C2同工酶发生反应。这两种小鼠同工酶表现出部分免疫同一性。针对ADH5位点编码的人chi-ADH同工酶（ADH同工酶III类）产生的免疫血清，与小鼠胃和肝脏中的ADH-B2同工酶发生反应。结果表明，小鼠ADH的A2和C2形式可能与ADH1、ADH2和ADH3位点编码的人ADH同工酶相关，而B2形式可能与ADH5位点编码的人ADH同工酶同源。
