Wilke T J
Clin Chem. 1983 Jan;29(1):74-9.
The thyroid hormone/thyroxin-binding globulin (TBG) ratio and the free thyroid hormone index (FTI) were compared in 372 subjects classified according to age, sex, and biochemical and clinical findings. Age-related variations in thyroid function tests were investigated, as was the relationship between triiodothyronine uptake and TBG. Men, but not women, showed significant age-dependent changes in concentrations of thyroid hormones. FTI was as good as the thyroid hormone/TBG ratio in hyperthyroidism and was a better index of thyroid status in pregnancy, TBG deficiency, and hypothyroidism. In addition, the triiodothyronine uptake correlated extremely well with TBG (r = -0.95, p less than 0.001) and was very efficient in detecting decreased and significantly increased concentrations of TBG. I conclude that FTI is a better discriminator of functional status of the thyroid over a wider range of TBG values than is the thyroid hormone/TBG ratio. Further, the triiodothyronine uptake test produced diagnostic information equivalent to that of TBG estimation and thus should not be replaced in routine use.
根据年龄、性别、生化及临床检查结果，对372名受试者的甲状腺激素/甲状腺素结合球蛋白（TBG）比值和游离甲状腺激素指数（FTI）进行了比较。研究了甲状腺功能检查中与年龄相关的变化，以及三碘甲状腺原氨酸摄取与TBG之间的关系。男性（而非女性）的甲状腺激素浓度呈现出显著的年龄依赖性变化。在甲状腺功能亢进症中，FTI与甲状腺激素/TBG比值效果相当，而在妊娠、TBG缺乏及甲状腺功能减退症中，FTI是更好的甲状腺状态指标。此外，三碘甲状腺原氨酸摄取与TBG的相关性极佳（r = -0.95，p < 0.001），在检测TBG浓度降低和显著升高方面非常有效。我得出结论，在更广泛的TBG值范围内，FTI比甲状腺激素/TBG比值更能区分甲状腺的功能状态。此外，三碘甲状腺原氨酸摄取试验产生的诊断信息与TBG测定相当，因此在常规应用中不应被取代。
