Mitomycin C extravasation injuries.

Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up. Ulceration may not appear for one to two weeks after initial injury. Wide local excision with subsequent split thickness skin grafting is recommended.