亮氨酸脑啡肽对大鼠下丘脑-垂体-甲状腺轴的影响。

Effects of leucine-enkephalin on hypothalamic-pituitary-thyroid axis in rats.

作者信息

Mitsuma T, Nogimori T

出版信息

Life Sci. 1983 Jan 17;32(3):241-8. doi: 10.1016/0024-3205(83)90036-x.

Abstract

Basal thyrotropin (TSH) levels in plasma and the TSH response to thyrotropin-releasing hormone (TRH) were inhibited after Leucine-enkephalin (L-EK) administration iv in rats. TRH and TSH responses to cold were inhibited after L-EK administration. In the L-DOPA, haloperidol or 5-hydoxytryptophan-treated rats, the inhibitory effect of L-EK on TSH release was restored. Findings suggested that L-EK acted both the hypothalamus and pituitary. Its inhibitory effects on TRH and TSH release at least partially mediated by interaction with amines in the central nervous system.

摘要

静脉注射亮氨酸脑啡肽（L-EK）后，大鼠血浆中的基础促甲状腺激素（TSH）水平以及TSH对促甲状腺激素释放激素（TRH）的反应受到抑制。给予L-EK后，TRH和TSH对寒冷的反应也受到抑制。在左旋多巴、氟哌啶醇或5-羟色氨酸处理的大鼠中，L-EK对TSH释放的抑制作用得以恢复。研究结果表明，L-EK作用于下丘脑和垂体。其对TRH和TSH释放的抑制作用至少部分是通过与中枢神经系统中的胺类相互作用介导的。