丙戊酸在儿童中的药代动力学：I. 多种抗癫痫药物治疗

Pharmacokinetics of valproic acid in children: I. Multiple antiepileptic drug therapy.

作者信息

Cloyd J C, Kriel R L, Fischer J H, Sawchuk R J, Eggerth R M

出版信息

Neurology. 1983 Feb;33(2):185-91. doi: 10.1212/wnl.33.2.185.

DOI:10.1212/wnl.33.2.185

Abstract

We studied the pharmacokinetics of valproic acid (VPA) in 37 children who were taking other antiepileptic drugs. Thirteen children were studied both after initial and while on maintenance valproic acid therapy. Significant differences occurred between initial and maintenance therapy in the mean apparent volume of distribution and in apparent VPA clearance, whereas VPA half-life remained relatively constant. Analysis of data in the 13 children studied on two occasions demonstrated wide intrapatient variability of VPA pharmacokinetics. Children taking VPA together with other antiepileptic medications generally require higher doses of VPA given more frequently.

摘要

我们研究了37名正在服用其他抗癫痫药物的儿童体内丙戊酸（VPA）的药代动力学。13名儿童在丙戊酸初始治疗阶段及维持治疗阶段均接受了研究。初始治疗和维持治疗阶段在平均表观分布容积和丙戊酸表观清除率方面存在显著差异，而丙戊酸半衰期则相对保持恒定。对13名接受了两次研究的儿童的数据分析表明，丙戊酸药代动力学在患者体内存在很大的变异性。同时服用丙戊酸和其他抗癫痫药物的儿童通常需要更频繁地给予更高剂量的丙戊酸。