Strauss R G, Snyder E L
Acta Haematol. 1983;69(1):9-14. doi: 10.1159/000206831.
The concentration of total glutathione (GSH + GSSG) and its depletion during oxidant stress were studied in neutrophils obtained from human neonates, their mothers and adult controls to determine if the previously reported increased susceptibility of infant neutrophils to oxidant damage could be related to glutathione deficiency. We found the basal level of glutathione to be lower and the oxidant-induced depletion of glutathione to be greater in infant neutrophils than in cells obtained from the blood of the infants' mothers and adult controls. In studies reported earlier, neutrophils from infants were found to be deficient in the oxidant protective enzymes glutathione peroxidase and catalase. These abnormalities, in a fashion similar to that observed for patients with congenital defects of glutathione and catalase metabolism, may render infant neutrophils prone to oxidant damage and consequent dysfunction.
研究了从人类新生儿、其母亲及成年对照者获取的中性粒细胞中总谷胱甘肽（GSH + GSSG）的浓度及其在氧化应激期间的消耗情况，以确定先前报道的婴儿中性粒细胞对氧化损伤易感性增加是否可能与谷胱甘肽缺乏有关。我们发现，婴儿中性粒细胞中谷胱甘肽的基础水平较低，且氧化诱导的谷胱甘肽消耗比从婴儿母亲血液及成年对照者获取的细胞中的更大。在早期报道的研究中，发现婴儿的中性粒细胞缺乏氧化保护酶谷胱甘肽过氧化物酶和过氧化氢酶。这些异常情况，与谷胱甘肽和过氧化氢酶代谢先天性缺陷患者所观察到的情况类似，可能使婴儿中性粒细胞易于受到氧化损伤及随之而来的功能障碍。
