Slutsky R, Mancini G B, Costello D, Hooper W, Verba J, Nelson T, Shabetai R, LeWinter M M
Am Heart J. 1983 Feb;105(2):243-8. doi: 10.1016/0002-8703(83)90522-7.
By manually assigning pulmonary regions of interest and deriving pulmonary time-activity (volume) curves, we were able to make count estimates of pulmonary blood volume (PBV) from gated cardiac blood pool scans. Five patients with coronary heart disease developed angina spontaneously while under a gamma camera. This produced an increase in cardiac volumes (p less than 0.05), a reduction in left ventricular ejection fraction (p less than 0.01), along with a marked increase in PBV (0.010 +/- 0.003 to 0.015 +/- 0.002 units, p less than 0.05). Nitroglycerin was then administered and reduced PBV in association with a return to normal in cardiac systolic function and size. In patients with stable chronic ischemic heart disease, sublingual nitroglycerin also reduced PBV (p less than 0.05), although not as much as when administered during an anginal episode. We conclude that gated imaging of the chest can be utilized to follow changes in PBV serially. These changes can be utilized to evaluate clinically important changes in hemodynamic status and the response to pharmacologic interventions.
通过手动指定肺部感兴趣区域并得出肺部时间-活性（容积）曲线，我们能够从门控心血池扫描中对肺血容量（PBV）进行计数估计。五名冠心病患者在γ相机监测下自发出现心绞痛。这导致心脏容积增加（p<0.05），左心室射血分数降低（p<0.01），同时肺血容量显著增加（从0.010±0.003单位增至0.015±0.002单位，p<0.05）。随后给予硝酸甘油，肺血容量降低，同时心脏收缩功能和大小恢复正常。在稳定的慢性缺血性心脏病患者中，舌下含服硝酸甘油也能降低肺血容量（p<0.05），尽管降低幅度不如心绞痛发作时给药那么大。我们得出结论，胸部门控成像可用于连续跟踪肺血容量的变化。这些变化可用于评估血流动力学状态的临床重要变化以及对药物干预的反应。
