Kim C S, O'Tuama L A, Mann J D, Roe C R
Brain Res. 1983 Jan 24;259(2):340-3. doi: 10.1016/0006-8993(83)91271-4.
Transport of the anionic herbicide 2,4-dichlorophenoxyacetic acid by choroid plexus is inhibited significantly by several short and medium chain acids. For both monocarboxylic and dicarboxylic homologs, inhibition clearly increases with chain length. It appears that organic acid compounds of longer chain length, higher brain uptake index, and highest inhibition of choroid plexus transport would be the ones producing the most significant increases in intracranial pressure in metabolic encephalopathy such as Reye's syndrome.
脉络丛对阴离子除草剂2,4-二氯苯氧乙酸的转运受到几种短链和中链酸的显著抑制。对于一元羧酸和二元羧酸同系物，抑制作用明显随链长增加。似乎链长更长、脑摄取指数更高且对脉络丛转运抑制作用最强的有机酸化合物，会是在诸如瑞氏综合征等代谢性脑病中导致颅内压显著升高的物质。
