Husain I, Tate S S
FEBS Lett. 1983 Feb 21;152(2):277-81. doi: 10.1016/0014-5793(83)80395-0.
The precursors of peptide hormones that possess a COOH-terminal alpha-amide group contain a glycine residue following the amino acid which is amidated in the hormone. Less than Glu-His-Pro-Gly was synthesized as a putative precursor of thyroliberin. Bovine pituitary neurosecretory granules were shown to contain an amide group-forming activity associated with an Mr of about 62 000 protein(s) which converts the tetrapeptide to thyroliberin.
具有COOH末端α-酰胺基的肽类激素前体在激素中被酰胺化的氨基酸之后含有一个甘氨酸残基。少于Glu-His-Pro-Gly的序列被合成为促甲状腺素释放激素的假定前体。牛垂体神经分泌颗粒被证明含有与大约62000 Mr的蛋白质相关的酰胺基形成活性，该活性可将四肽转化为促甲状腺素释放激素。
