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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Int J Biochem. 1983;15(1):57-64. doi: 10.1016/0020-711x(83)90011-3.

Pteridine cofactor of phenylalanine hydroxylase (EC 1.14.16.1) and dihydropteridine reductase (EC 1.6.99.7) in the phenylalanine hydroxylating system have been studied in the fetal rat liver. 2. Activities of pteridine cofactor and dihydropteridine reductase were measured as about 6 and 50%, respectively, of the levels of adult liver in the liver from fetuses on 20 days of gestation, at this stage the activity of phenylalanine hydroxylase was almost negligible in the liver. 3. Development of the activity of sepiapterin reductase (EC 1.1.1.153), an enzyme involved in the biosynthesis of pteridine cofactor, was studied in rat liver during fetal (20-22 days of gestation), neonatal and adult stages comparing with the activity of dihydrofolate reductase (EC 1.5.1.3). Activities of the enzymes were about 80 and 50%, respectively, of the adult levels at 20 days of gestation. 4. Some characteristics of sepiapterin reductase and dihydropteridine reductase of fetal liver were reported.

已在胎鼠肝脏中研究了苯丙氨酸羟化酶（EC 1.14.16.1）和二氢蝶啶还原酶（EC 1.6.99.7）在苯丙氨酸羟化系统中的蝶啶辅因子。2. 在妊娠20天胎儿的肝脏中，蝶啶辅因子和二氢蝶啶还原酶的活性分别测定为成年肝脏水平的约6%和50%，在此阶段肝脏中苯丙氨酸羟化酶的活性几乎可以忽略不计。3. 在胎儿期（妊娠20 - 22天）、新生儿期和成年期的大鼠肝脏中，研究了参与蝶啶辅因子生物合成的酶——蝶啶还原酶（EC 1.1.1.153）的活性发展，并与二氢叶酸还原酶（EC 1.5.1.3）的活性进行比较。在妊娠20天时，这些酶的活性分别约为成年水平的80%和50%。4. 报道了胎儿肝脏中蝶啶还原酶和二氢蝶啶还原酶的一些特性。

Int J Biochem. 1983;15(1):57-64. doi: 10.1016/0020-711x(83)90011-3.

Pteridine cofactor of phenylalanine hydroxylase (EC 1.14.16.1) and dihydropteridine reductase (EC 1.6.99.7) in the phenylalanine hydroxylating system have been studied in the fetal rat liver. 2. Activities of pteridine cofactor and dihydropteridine reductase were measured as about 6 and 50%, respectively, of the levels of adult liver in the liver from fetuses on 20 days of gestation, at this stage the activity of phenylalanine hydroxylase was almost negligible in the liver. 3. Development of the activity of sepiapterin reductase (EC 1.1.1.153), an enzyme involved in the biosynthesis of pteridine cofactor, was studied in rat liver during fetal (20-22 days of gestation), neonatal and adult stages comparing with the activity of dihydrofolate reductase (EC 1.5.1.3). Activities of the enzymes were about 80 and 50%, respectively, of the adult levels at 20 days of gestation. 4. Some characteristics of sepiapterin reductase and dihydropteridine reductase of fetal liver were reported.

已在胎鼠肝脏中研究了苯丙氨酸羟化酶（EC 1.14.16.1）和二氢蝶啶还原酶（EC 1.6.99.7）在苯丙氨酸羟化系统中的蝶啶辅因子。2. 在妊娠20天胎儿的肝脏中，蝶啶辅因子和二氢蝶啶还原酶的活性分别测定为成年肝脏水平的约6%和50%，在此阶段肝脏中苯丙氨酸羟化酶的活性几乎可以忽略不计。3. 在胎儿期（妊娠20 - 22天）、新生儿期和成年期的大鼠肝脏中，研究了参与蝶啶辅因子生物合成的酶——蝶啶还原酶（EC 1.1.1.153）的活性发展，并与二氢叶酸还原酶（EC 1.5.1.3）的活性进行比较。在妊娠20天时，这些酶的活性分别约为成年水平的80%和50%。4. 报道了胎儿肝脏中蝶啶还原酶和二氢蝶啶还原酶的一些特性。