Pawelec G, Shaw S, Schneider M, Rehbein A, Wernet P
Immunogenetics. 1983;17(2):179-88. doi: 10.1007/BF00364757.
The HLA-linked "SB" antigens comprise a new segregant series of B-cell alloantigens mapping between HLA-DR and glyoxylase. They can be detected by secondary proliferative responses of lymphocytes primed against HLA-A, B, C, DR, MB- and MT-compatible stimulators. To asses genetic complexity of the SB-gene region, alloreactive cloned T-cell lines were derived from four reagents detecting specificities designated SB2 and SB3. In two families, products detected by seven different clones segregated with the HLA haplotypes bearing the SB2 or SB3 specificities as recognized by the uncloned reagents. There were no indications that the cloned cells differed from the oligoclonal reagents in their fine specificity. In contrast to previous results with an SB4-associated specificity, in population studies of 25 SB2-positive and 23 SB3-positive donors, no evidence could be found for subtypes of either specificity. Thus, even at the level of recognition by cloned T-cells, both SB2 and SB3 appear to be remarkably homogeneous in the population.
与HLA连锁的“SB”抗原构成了一个新的B细胞同种异体抗原分离系列，定位于HLA - DR和乙二醛酶之间。它们可通过针对HLA - A、B、C、DR、MB和MT相容刺激物致敏的淋巴细胞的二次增殖反应来检测。为评估SB基因区域的遗传复杂性，从检测指定为SB2和SB3特异性的四种试剂中获得了同种异体反应性克隆T细胞系。在两个家系中，七个不同克隆检测到的产物与未克隆试剂识别的携带SB2或SB3特异性的HLA单倍型一起分离。没有迹象表明克隆细胞在精细特异性方面与寡克隆试剂不同。与先前关于SB4相关特异性的结果相反，在对25名SB2阳性和23名SB3阳性供体的群体研究中，未发现任何一种特异性存在亚型的证据。因此，即使在克隆T细胞的识别水平上，SB2和SB3在群体中似乎也非常均一。
