Chan J C
J Pediatr. 1983 Mar;102(3):327-40. doi: 10.1016/s0022-3476(83)80644-1.
In the past decade major advances in our understanding of renal tubular hydrogen ion secretion and bicarbonate reabsorption have provided new insight into the pathophysiology of renal tubular acidosis. Thus "fragment to fragment clings" and the number of disorders categorized within the syndrome grows, until we have come to know and name four types, with many subtypes. We hope this new perspective provides a basis for the physician to recognize renal tubular acidosis in its several forms so that an informed decision may be arrived at in choosing the best therapy. The physician may also be prepared to reasonably project the prognosis for each patient. We also hope that our detailed examination of renal acidification will provide a reference for delineation of new clinical expressions of acid-base disorders and kidney malfunction certain to be described in the years ahead.
在过去十年中，我们对肾小管氢离子分泌和碳酸氢盐重吸收的认识取得了重大进展，这为深入了解肾小管酸中毒的病理生理学提供了新的视角。因此，“碎片与碎片相互依附”，该综合征所涵盖的疾病数量不断增加，直至我们认识并命名了四种类型以及许多亚型。我们希望这一新视角能为医生识别多种形式的肾小管酸中毒提供依据，以便在选择最佳治疗方案时做出明智的决策。医生还可以据此合理预测每位患者的预后。我们也希望对肾脏酸化的详细研究能为今后几年描述酸碱平衡紊乱和肾功能不全的新临床表现提供参考。
