Morrow C E, Sutherland D E, Steffes M W, Najarian J S, Bach F H
Science. 1983 Mar 18;219(4590):1337-9. doi: 10.1126/science.6402817.
Rejection of mouse pancreatic islet allografts occurred in a high percentage of donor recipient combinations identical for H-21-region antigens and differing at H-2K and H-2K + H-2D without I-region disparities. The results suggest that disparities in major histocompatibility complex antigens of class I (H-2K and H-2D) alone are capable of eliciting islet allograft rejection, and that lack of a stimulus from class II (I-region) alloantigens does not ensure permanent islet allograft survival.
