妊娠剧吐患者血清反三碘甲状腺原氨酸升高。

Increased serum reverse triiodothyronine in patients with hyperemesis gravidarum.

作者信息

Juras N, Banovac K, Sekso M

出版信息

Acta Endocrinol (Copenh). 1983 Feb;102(2):284-7. doi: 10.1530/acta.0.1020284.

DOI:10.1530/acta.0.1020284

Abstract

Thyroid function and pituitary responsiveness to TRH were studied in patients with hyperemesis gravidarum. Serum T3 and T4 concentrations were normal. Serum TBG levels in hyperemesis were normal for gestation, and the T4:TBG ratio was in the euthyroid range. In all patients a normal TSH response to TRH was found. Mean serum rT3 concentration was increased by 31% as compared to a control group of normal pregnant women (P less than 0.001). The data suggest that in patients with hyperemesis gravidarum there is: (a) normal function of the thyroid gland and pituitary-thyroid axis, (b) an enhanced peripheral conversion of T4 to rT3.

摘要

对妊娠剧吐患者的甲状腺功能及垂体对促甲状腺激素释放激素（TRH）的反应性进行了研究。血清三碘甲状腺原氨酸（T3）和甲状腺素（T4）浓度正常。妊娠剧吐患者的血清甲状腺素结合球蛋白（TBG）水平与妊娠周数相符，T4:TBG比值处于甲状腺功能正常范围。所有患者对TRH的促甲状腺激素（TSH）反应均正常。与正常孕妇对照组相比，血清反三碘甲状腺原氨酸（rT3）平均浓度升高了31%（P<0.001）。数据表明，妊娠剧吐患者存在：（a）甲状腺及垂体-甲状腺轴功能正常，（b）T4向rT3的外周转化增强。