Cochrane R L, Powell J G, Mason N R, Rathmacher R P
Biol Reprod. 1983 Feb;28(1):134-41. doi: 10.1095/biolreprod28.1.134.
A potent prostaglandin synthesis inhibitor (cyclooxygenase inhibitor), 2(p-biphenyl) propionic acid (BPPA), was administered subcutaneously at the dose of 1 mg twice daily to pseudopregnant and cyclic rats. It was found to prolong the duration of pseudopregnancy by about 10 days and to have little or no effect on estrous cycle length. It did not block ovulation and had little effect on ovulation rate in cyclic rats. BPPA was given to pseudopregnant rats in two trials (one in October-December and the other in March-May) to determine its effect on ovarian weight and plasma progesterone concentration on Days 14, 15 and 16 (Day 0=day of induction of pseudopregnancy). BPPA significantly (P less than 0.001) increased plasma progesterone concentration and reduced ovarian weight. The present data support the hypothesis that prostaglandins cause the normal functional demise of the corpora lutea of pseudopregnancy in the intact rat, and that depressing their synthesis will prolong the functional life span of the corpora lutea.
一种强效前列腺素合成抑制剂（环氧化酶抑制剂），2-（对-联苯基）丙酸（BPPA），以每日两次、每次1毫克的剂量皮下注射给假孕大鼠和正常发情周期的大鼠。结果发现，它可使假孕持续时间延长约10天，而对发情周期长度几乎没有影响。它不阻断排卵，对正常发情周期大鼠的排卵率影响很小。在两项试验中（一项在10月至12月，另一项在3月至5月）给假孕大鼠注射BPPA，以确定其对第14、15和16天（第0天=诱导假孕之日）卵巢重量和血浆孕酮浓度的影响。BPPA显著（P<0.001）提高了血浆孕酮浓度，并降低了卵巢重量。目前的数据支持这样的假说，即前列腺素导致完整大鼠假孕黄体的正常功能性退化，而抑制其合成将延长黄体的功能寿命。
