Gordon W L, Sherwood O D
Biol Reprod. 1983 Feb;28(1):154-60. doi: 10.1095/biolreprod28.1.154.
The relationship of the antepartum elevation in serum relaxin levels in pregnant rats to luteolysis was examined by determining the effects of the luteolysin prostaglandin F2 alpha (PGF2 alpha) and the prostaglandin synthetase inhibitor indomethacin on antepartum serum relaxin levels, as well as on luteolysis and birth. Intravenous administration of PGF2 alpha on the morning of Day 20 elevated serum relaxin levels approximately fourfold within 15 min. Administration of the prostaglandin synthetase inhibitor indomethacin from Day 19 until Day 23 protracted luteolysis, delayed or prevented birth, and delayed the antepartum elevation of serum relaxin levels, until after indomethacin treatment had been terminated. Collectively, these results indicate that prostaglandins, in particular PGF2 alpha, may promote the antepartum increase in serum relaxin levels, as well as luteolysis and birth in rats.
通过测定溶黄体素前列腺素F2α（PGF2α）和前列腺素合成酶抑制剂吲哚美辛对产前血清松弛素水平以及黄体溶解和分娩的影响，研究了孕鼠产前血清松弛素水平升高与黄体溶解之间的关系。在第20天上午静脉注射PGF2α，15分钟内血清松弛素水平升高约四倍。从第19天至第23天给予前列腺素合成酶抑制剂吲哚美辛，可延长黄体溶解时间，延迟或阻止分娩，并延迟产前血清松弛素水平的升高，直至吲哚美辛治疗终止后才出现升高。总的来说，这些结果表明，前列腺素，特别是PGF2α，可能促进大鼠产前血清松弛素水平的升高以及黄体溶解和分娩。
