Merkur'eva R V, Aulika B V, Skvortsova N N, Iakimova E R, Konstantinova I N
Biull Eksp Biol Med. 1983 Mar;95(3):119-21.
Based on an analysis of correlations between variation in the amount of alveolar macrophages of rat lungs and activity of enzymes localized in these cells (acid phosphatase, beta-galactosidase, beta-glucosidase, lactate dehydrogenase), the cytobiochemical changes in the function of pulmonary alveolar macrophages have been defined with the use of a model of permanent inhalation exposure to sulfur dioxide. The use of the model enables the dilimitation of the stages of defence-compensatory reactions and their transition to an unfavourable biological effect. The results obtained may serve as a theoretical basis for recommending a wider experimental application of the tests in question during regulation of environmental factors.
基于对大鼠肺中肺泡巨噬细胞数量变化与这些细胞中定位的酶（酸性磷酸酶、β-半乳糖苷酶、β-葡萄糖苷酶、乳酸脱氢酶）活性之间相关性的分析，利用二氧化硫长期吸入暴露模型确定了肺泡巨噬细胞功能的细胞生化变化。该模型的使用能够界定防御代偿反应的阶段及其向不利生物学效应的转变。所得结果可为在环境因素调控期间推荐更广泛地实验应用相关检测提供理论依据。
