Murrills A J, Barrington P, Harris P D, Wheeler T
Br Med J (Clin Res Ed). 1983 Mar 26;286(6370):1009-12. doi: 10.1136/bmj.286.6370.1009.
A randomised and double blind study of 100 subjects and 50 controls was performed to confirm or refute a report from Cardiff in 1975 that continuous Doppler ultrasound, as used in fetal heart rate monitoring, increases fetal movement by over 90%. The results showed such an effect to be most unlikely (power greater than 0.99). A total of 150 pregnant mothers recorded fetal movements for 30 minutes while connected to a specially modified cardiotocograph, the ultrasound being switched on at random for either the first or second 15 minutes in 100 of the patients. The mean difference in 15 minute movement count, with and without ultrasound, among the 100 patients was 0.2 of a movement (SD 12.7; p greater than 0.6 by two tailed Wilcoxon matched pairs signed ranks test). The control group showed a mean difference of 2.6 movements (SD 12.1; p greater than 0.2). Results of a pilot study suggested that the observations in the earlier report may have been influenced by mechanisms unrelated to ultrasound.
对100名受试者和50名对照者进行了一项随机双盲研究，以证实或反驳1975年来自加的夫的一份报告，该报告称用于胎儿心率监测的连续多普勒超声可使胎儿活动增加90%以上。结果表明这种效应极不可能出现（检验效能大于0.99）。共有150名孕妇在连接到经过特殊改装的胎心监护仪时记录30分钟的胎儿活动情况，其中100名患者的超声在第一个或第二个15分钟随机开启。在这100名患者中，有超声和无超声时15分钟胎动计数的平均差异为0.2次胎动（标准差12.7；双侧威尔科克森配对符号秩检验p大于0.6）。对照组的平均差异为2.6次胎动（标准差12.1；p大于0.2）。一项初步研究的结果表明，早期报告中的观察结果可能受到了与超声无关的机制的影响。
