Díaz Gómez M I, Godoy H M, Villarruel M C, Castro J A
Cancer Lett. 1983 Mar;18(2):157-62. doi: 10.1016/0304-3835(83)90062-9.
No evidence for liver necrosis was observed at 24, 48 or 72 h after injection of dimethylnitrosamine (DMN) (70 mg/kg, i.p.) to pigeons. The assessment of possible liver necrosis was made by determination of isocitric dehydrogenase (ICD), glutamate oxalacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) in plasma. The ability of pigeon liver slices to metabolize CO2 or to give covalent binding of reactive metabolites to nucleic acids was 24 times smaller than that for rat. Similarly, the pigeon liver microsomes or 9000 X g supernatant have DMN-demethylase activity or ability to activate DMN to reactive metabolites that bind covalently to proteins very close to zero. Results suggest that resistance of pigeon liver to DMN acute effects is related to its lack of ability for DMN metabolic activation.
给鸽子腹腔注射二甲基亚硝胺（DMN）（70毫克/千克）后24、48或72小时，未观察到肝坏死的证据。通过测定血浆中的异柠檬酸脱氢酶（ICD）、谷草转氨酶（GOT）和谷丙转氨酶（GPT）来评估可能的肝坏死情况。鸽子肝切片代谢二氧化碳或使反应性代谢产物与核酸共价结合的能力比大鼠小24倍。同样，鸽子肝微粒体或9000×g上清液的DMN去甲基酶活性或激活DMN生成与蛋白质共价结合的反应性代谢产物的能力几乎为零。结果表明，鸽子肝脏对DMN急性效应的抗性与其缺乏DMN代谢激活能力有关。
