8-甲氧基补骨脂素与黄曲霉毒素B1在长波紫外线下的光致癌性。
Photocarcinogenicity of 8-methoxypsoralen and aflatoxin B1 with longwave ultraviolet light.
作者信息
Nagayo K, Way B H, Tran R M, Song P S
出版信息
Cancer Lett. 1983 Mar;18(2):191-8. doi: 10.1016/0304-3835(83)90067-8.
The carcinogenicity of 8-methoxypsoralen (8-MOP) and aflatoxin B1 (AFB1) with longwave ultraviolet light (UVA) to hairless mouse skin was investigated. Skin tumors were induced efficiently by 8-MOP + UVA, and the time to 50% tumor incidence was about 24 weeks. Histopathologically, some tumors were squamous cell carcinomas. AFB1 did not show any phototoxic and photocarcinogenic effects on mouse skin in this study. Although the structure and the photoreactivity of AFB1 to DNA were similar to those of 8-MOP, the photocarcinogenic response of these compounds to mouse skin was quite different.
研究了8-甲氧基补骨脂素（8-MOP）和黄曲霉毒素B1（AFB1）与长波紫外线（UVA）对无毛小鼠皮肤的致癌性。8-MOP + UVA可有效诱导皮肤肿瘤，50%肿瘤发生率的时间约为24周。组织病理学检查显示，部分肿瘤为鳞状细胞癌。在本研究中，AFB1对小鼠皮肤未表现出任何光毒性和光致癌作用。尽管AFB1的结构及其对DNA的光反应性与8-MOP相似，但这些化合物对小鼠皮肤的光致癌反应却大不相同。
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