Woloschak G E, Tomasi T B
Crit Rev Immunol. 1983;4(1):1-18.
Certain recent developments (since previous reviews) concerning the chemistry and mechanisms of transport of IgA antibodies will be reported. However, the major theme of the review will involve the morphological and functional characteristics of the cells found in mucosal tissues. Particular emphasis will be given to the gastrointestinal tract since considerably more data are available for this organ. The proposed mechanism by which antigen is processed in mucosal lymphoid tissues will be reviewed, including data pertinent to the commitment of the mucosal lymphocytes to IgA production. Emphasis will also be placed on cell migration patterns from the lymphoid tissues of the gut and lungs to other distal sites. The biological and medical implications, particularly in regard to immunizations at one site giving rise to immunity at distal sites, will be discussed in detail. The proposed mechanisms and significance of orally induced tolerance will also be reviewed.
将报告近期（自上次综述以来）有关IgA抗体化学及转运机制的某些进展。然而，本综述的主要主题将涉及黏膜组织中细胞的形态学和功能特征。鉴于胃肠道有更多的数据可用，将特别强调胃肠道。将综述黏膜淋巴组织中抗原加工的拟议机制，包括与黏膜淋巴细胞产生IgA相关的数据。还将重点关注细胞从肠道和肺部的淋巴组织迁移到其他远端部位的模式。将详细讨论其生物学和医学意义，特别是关于在一个部位进行免疫接种可在远端部位产生免疫力的情况。还将综述口服诱导耐受的拟议机制及其意义。
