Rodeck U, Dominick H C
Monatsschr Kinderheilkd. 1983 Jan;131(1):19-22.
In 35 infants trehalose-load-tests were carried out, biopsies of the intestinal mucosa of each patient were taken, and examined histologically. Furthermore, the enzyme activities of trehalase and lactase in each biopsy were determined. It was possible to demonstrate that morphology and function of the intestinal mucosa correlate differently depending on the severity of the mucosal damage. If there is only moderate mucosal damage, a rather weak correlation is seen either for the trehalose-load-test or for the disaccharidase activities with morphological changes. If damage was absent or severe, correlation improved. Both methods in comparison show a better correlation between trehalase activity and morphology than between trehalose-load-test and morphology. Furthermore, trehalase activity corroborated the histological findings better than lactase activity.
对35名婴儿进行了海藻糖负荷试验，采集了每位患者的肠黏膜活检样本并进行组织学检查。此外，还测定了每个活检样本中海藻糖酶和乳糖酶的酶活性。结果表明，肠黏膜的形态和功能根据黏膜损伤的严重程度呈现出不同的相关性。如果只有中度黏膜损伤，海藻糖负荷试验或双糖酶活性与形态学变化之间的相关性较弱。如果没有损伤或损伤严重，相关性则会增强。相比之下，两种方法都显示出海藻糖酶活性与形态学之间的相关性优于海藻糖负荷试验与形态学之间的相关性。此外，海藻糖酶活性比乳糖酶活性更能证实组织学检查结果。
