药物信号增强去垂体大鼠的吗啡耐受性发展。

Drug signals enhance morphine tolerance development in hypophysectomized rats.

作者信息

Tiffany S T, Petrie E C, Martin E M, Baker T B

出版信息

Psychopharmacology (Berl). 1983;79(1):84-5. doi: 10.1007/BF00433022.

Abstract

Hypophysectomized and sham-operated (normal) rats were given morphine (5 mg/kg) either paired or unpaired with distinctive environmental cues. Both hypophysectomized and normal animals developed analgesic tolerance when drug effects were signaled, but little tolerance was evident in either surgery group when drug was unsignaled. Results suggest that the pituitary is not critical to associational tolerance development.

摘要

对垂体切除和假手术（正常）的大鼠给予吗啡（5毫克/千克），同时伴有或不伴有独特的环境线索。当药物效应有提示时，垂体切除和正常的动物都会产生镇痛耐受性，但当药物无提示时，两个手术组均未表现出明显的耐受性。结果表明，垂体对于关联性耐受性的形成并非至关重要。